People

Gregory Dwyer, PhD

My lab studies the ecology and evolution of pathogens, and how pathogens drive the evolution and population dynamics of their hosts. Two major questions that we ask are, how does host variation affect pathogen epidemics and pathogen evolution? And, how does pathogen variation modulate the effects of pathogens on host population dynamics? We attempt to answer these questions by first constructing mathematical models of host-pathogen dynamics, and then by testing the models using a combination of experiments and observations of epidemics in nature. We use insect pathogens as test systems, but the general usefulness of the advanced computing techniques that we use has led to studies of human papillomavirus and salmon conservation. Insect pathogens play a key role in preventing the destruction of forests, and this role has driven new projects on the ecology and economics of biological control, and on the effects of climate change on insect outbreaks.

University of Washington
Seattle, WA
Ph.D. - Zoology
1990

Cornell University
Ithaca, NY
B.A. with Honors - Biology
1983

Use of a mechanistic growth model in evaluating post-restoration habitat quality for juvenile salmonids.
Polivka CM, Mihaljevic JR, Dwyer G. Use of a mechanistic growth model in evaluating post-restoration habitat quality for juvenile salmonids. PLoS One. 2020; 15(6):e0234072.
PMID: 32579548

An Empirical Test of the Role of Small-Scale Transmission in Large-Scale Disease Dynamics.
Mihaljevic JR, Polivka CM, Mehmel CJ, Li C, Dukic V, Dwyer G. An Empirical Test of the Role of Small-Scale Transmission in Large-Scale Disease Dynamics. Am Nat. 2020 04; 195(4):616-635.
PMID: 32216670

Stochasticity and Infectious Disease Dynamics: Density and Weather Effects on a Fungal Insect Pathogen.
Kyle CH, Liu J, Gallagher ME, Dukic V, Dwyer G. Stochasticity and Infectious Disease Dynamics: Density and Weather Effects on a Fungal Insect Pathogen. Am Nat. 2020 03; 195(3):504-523.
PMID: 32097039

Combined Effects of Natural Enemies and Competition for Resources on a Forest Defoliator: A Theoretical and Empirical Analysis.
Gallagher ME, Dwyer G. Combined Effects of Natural Enemies and Competition for Resources on a Forest Defoliator: A Theoretical and Empirical Analysis. Am Nat. 2019 12; 194(6):807-822.
PMID: 31738098

Untangling the dynamics of persistence and colonization in microbial communities.
Ranjeva SL, Mihaljevic JR, Joseph MB, Giuliano AR, Dwyer G. Untangling the dynamics of persistence and colonization in microbial communities. ISME J. 2019 12; 13(12):2998-3010.
PMID: 31444482

Effects of multiple sources of genetic drift on pathogen variation within hosts.
Kennedy DA, Dwyer G. Effects of multiple sources of genetic drift on pathogen variation within hosts. PLoS Biol. 2018 03; 16(3):e2004444.
PMID: 29590105

Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity.
Ranjeva SL, Baskerville EB, Dukic V, Villa LL, Lazcano-Ponce E, Giuliano AR, Dwyer G, Cobey S. Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13573-13578.
PMID: 29208707

Eco-Evolutionary Theory and Insect Outbreaks.
Páez DJ, Dukic V, Dushoff J, Fleming-Davies A, Dwyer G. Eco-Evolutionary Theory and Insect Outbreaks. Am Nat. 2017 Jun; 189(6):616-629.
PMID: 28514636

Genotype-by-genotype interactions between an insect and its pathogen.
Hudson AI, Fleming-Davies AE, Páez DJ, Dwyer G. Genotype-by-genotype interactions between an insect and its pathogen. J Evol Biol. 2016 12; 29(12):2480-2490.
PMID: 27622965

Phenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence.
Fleming-Davies AE, Dwyer G. Phenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence. Am Nat. 2015 Dec; 186(6):797-806.
PMID: 26655986

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Quantrell Award for Excellence in Undergraduate Teaching
University of Chicago
2014

George Mercer Award for an Outstanding Paper by an Author of Age Less Than 40
Ecological Society of America
1998